Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

被引：0
|
作者：
LIU Ye-zhuo
机构：
来源：
Chemical Research in Chinese Universities | 2012年 / 28卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Biopolymer; Nanoparticle; Graft copolymer; Self-assembly;
D O I：
暂无
中图分类号：
O631.3 [高聚物的化学性质];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Chitosan-graft-poly(L-glutamic acid)(CS-g-PGA) copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.
引用
收藏
页码：921 / 925
页数：5
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