Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease

BACKGROUND Percutaneous coronary intervention(PCI) in patients with unprotected left main coronary artery disease(ULMCAD) is increasing strategy in coronary artery patients. However, there is a lack of knowledge on the impact of sex on outcomes of patients undergoing ULMCAD PCI.METHODS From January 2004 to December 2015, there were 3,960 patients undergoing ULMCAD PCI at our institution, including 3,121(78.8%) men and 839(21.2%) women. The clinical outcome included the incidence of major adverse cardiac events(MACE)(the composite of all-cause death, myocardial infarction(MI), and revascularization), all-cause death, MI, revascularization at three years follow-up.RESULTS Compared with men, women had not significantly different MACE(14.7% vs. 14.6%, P = 0.89, all-cause death(3.5%vs. 3.7%, P = 0.76), MI(5.0% vs. 4.3%, P = 0.38), revascularization(9.1% vs. 8.9%, P = 0.86), respectively. After adjustment, rates of MACE(HR = 1.49; 95% CI: 1.24-1.81; P < 0.000 1) and all-cause death(HR = 1.65; 95% CI: 1.09-2.48; P = 0.017) occurred more frequently in male patients, as well as revascularization(HR = 1.46; 95% CI: 1.16-1.85; P = 0.001).CONCLUSION In this analysis, compared to men, women undergoing ULMCAD PCI have better outcomes of MACE, allcause death, and revascularization.