Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer cells. Peptidetargeted sonodynamic therapy(SDT) can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven therapy. Herein, we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting, which constituted a nano sonosensitizer(T-cRGD NPs) for fluorescence imaging-guided sonodynamic therapy. A comparable sonosensitizer(T-PEG NPs) without the targeting unit was also prepared for illustration of therapeutic performance. Attribute to the role of peptide targeting, T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in vitro. The imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.