Epac1与神经性疼痛的研究进展附视频

被引:3
作者
袁欢欢
李琳
李全民
机构
[1] 火箭军总医院内分泌科
关键词
神经性疼痛; 环腺苷酸; 鸟嘌呤核苷酸转化因子交换蛋白1;
D O I
暂无
中图分类号
R402 [];
学科分类号
摘要
鸟嘌呤核苷酸转化因子交换蛋白1(Epac1)是一种新型的环腺苷酸传感器,调节细胞的几个关键过程,如Ca2+调控、肌肉收缩、细胞分泌、离子通道传递、学习与记忆、细胞的生长和分化、凋亡和炎症。Epac1在神经性疼痛的进展中发挥关键作用,Epac1激活有助于神经性疼痛引起的异常性疼痛的进展,具体信号转导机制尚不清楚,可能与激活蛋白激酶C、丝裂原活化蛋白激酶以及Ca2+内流有关。Epac1在神经疼痛的研究仅限于动物实验和细胞实验,未来有望在人体进行试验研究,使其成为治疗神经性疼痛的新靶点。
引用
收藏
页码:868 / 872
页数:5
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