Gadd45在恶性肿瘤中的研究进展

被引：3

作者：

王赟

季洪亮

机构：

[1] 哈尔滨医科大学附属第一医院

来源：

中国实验诊断学 | 2013年 / 17卷 / 06期

关键词：

细胞周期停滞; 启动子; 致癌基因; Gadd45; 凋亡; 髓性白血病; 甲基化; 烷基化; 肿瘤生长; ITD; 恶性肿瘤; 胰腺导管癌; 家族成员; FLT; AML; 肝癌; 肝脏肿瘤; 乳腺癌; 乳腺肿瘤; 多西紫杉醇; 应激反应;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

<正>Gadd45与DNA损伤修复密切相关,全称为生长阻滞与DNA损伤诱生蛋白45(growth arrest anddNA damage inducible protein 45,Gadd45),其基因家族属于p53和BRCA1的下游靶基因,在细胞生存及细胞凋亡中发挥重要作用。Gadd45家族由Gadd45α、Gadd45β和Gadd45γ三个成员组成,它们的基因排列序列非常相似,通常会在环境损伤因子作用下,随DNA修复过程的启动而诱导产生。电离辐射及紫外线照射等多种损伤因素可快速诱导产

引用

页码：1155 / 1158

页数：4

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