Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro

被引：0
作者：
PENG Bo CHEN Hanyang TAN Yadi JIN Meilin CHEN Huanchun GUO Aizhen Laboratory of Animal Virology College of Veterinary Medicine Huazhong Agricultural University Wuhan China National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan China [1 ,1 ,1 ,2 ,1 ,2 ,1 ,2 ,1 ,2 ,1 ,430070 ,2 ,430070 ]
机构：
来源：
Science in China(Series C:Life Sciences) | 2006年 / 02期
关键词：
avian infectious bronchitis virus; phage display; peptides;
D O I：
暂无
中图分类号：
S852.65 [家畜病毒学];
学科分类号：
090601 ;
摘要：
Purified avian infectious bronchitis virus (IBV) was used to screen a random phage dis-play peptide library. After the fourth panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells and blocked IBV haemagglutination. One linear peptide “GSH HRH VHS PFV” from the positive phages with the highest neutralization titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development of antiviral therapeutics for IBV and studying the determinants for viral and cell interac-tion.
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页码：158 / 163
页数：6
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