重组胶原蛋白的产业发展历程和生物医学应用前景展望

被引：24

作者：

傅容湛 ^{[1
]}

范代娣 ^{[1
,2
]}

杨婉娟 ^{[3
]}

陈亮 ^{[3
]}

曲词 ^{[4
]}

杨树林 ^{[5
]}

徐丽明 ^{[3
]}

机构：

[1] 西北大学化工学院

[2] 陕西巨子生物技术有限公司

[3] 中国食品药品检定研究院

[4] 河北考力森生物科技有限公司

[5] 南京理工大学环境与生物工程学院

来源：

生物工程学报 | 2022年 / 09期

基金：

国家重点研发计划;

关键词：

重组胶原蛋白; 重组类人胶原蛋白; 重组胶原蛋白变体; 重组蛋白表达体系; 生物医学应用;

D O I：

10.13345/j.cjb.220061

中图分类号：

R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

重组胶原蛋白作为天然动物组织胶原的替代物具有广泛应用于生物材料、生物医学等领域的潜力。种类繁多的重组胶原蛋白类型及其衍生体在多种表达系统中可实现一定规模的产业化生产，为探索和拓展重组胶原蛋白的临床应用奠定了基础。文中简述了重组胶原蛋白的不同表达体系，如大肠杆菌、酵母、植物、昆虫、哺乳动物和人类细胞表达体系，重组胶原蛋白的优势及潜在的应用和局限。着重介绍了目前重组胶原蛋白生产，包括不同表达体系的构建策略和重组胶原蛋白羟基化修饰等方面的研究进展，总结了重组胶原蛋白在生物医药领域的应用及应用基础研究和应用前景展望。

引用

页码：3228 / 3242

页数：15

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