Aggregation-induced T/T contrast enhancement for magnetic resonance imaging-guided intraoperative surgery

被引：0

作者：

Wenbo Sun ^{[1
,2
]}

Bin Yu ^{[1
]}

Dianshuai Huang ^{[1
]}

Chunhuan Jiang ^{[1
]}

Wei Wang ^{[1
]}

Jianhua Liu ^{[3
]}

Zonghua Wang ^{[2
]}

Lehui Lu ^{[1
]}

机构：

[1] State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences

[2] College of Chemistry and Chemical Engineering,Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials,Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment,Qingdao Univers

[3] Department of Radiology,Second Hospital of Jilin University

来源：

Science China(Chemistry) | 2024年 / 06期

关键词：

D O I：

暂无

中图分类号：

R445.2 [核磁共振成像]; O657.2 [磁化学分析法];

学科分类号：

100207 ; 070302 ; 081704 ;

摘要：

Magnetic resonance imaging（MRI） plays an important role in precision medicine that is hampered by the lack of contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention. Herein, we demonstrate a DNA-based MRI probe that overcomes previous single-mode enhancement and provides a mechanism of action for aggregationinduced dual-modal MRI signal enhancement. A facile method is developed to produce aggregated T1/T2 dual-modal NaGdF4:Dy@PDA-DNA（PDA = polydopamine） MRI probes. When aggregated, this probe can further amplify MRI signal intensity and exhibit improved geometrical and positional stability in vivo. The performance of the NaGdF4:Dy@PDA-DNA MRI probe toward MRI-guided preoperative planning and visualization-guided surgery is verified using an orthotopic tumor-bearing mouse model. The result shows that the rapid metabolism of the degraded probe leads to the mitigation of long-term toxic effects.Therefore, the developed high-performance MRI probe is of great significance for enhancing MRI diagnostic accuracy into precision medical therapeutic interventions.

引用

页码：2046 / 2055

页数：10

共 34 条

[1] 按需降解的核磁共振成像纳米探针（英文） [J].

孙文博 ;

王宗花 ;

刘建华 ;

姜春环 ;

陈伟华 ;

于滨 ;

王唯 ;

逯乐慧 .

Science Bulletin, 2021, 66 (07) :676-684

[2]

Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer[J] Yin Mingming;Liu Xiaoming;Lei Ziqiao;Gao Yuting;Liu Jiacheng;Tian Sidan;Liang Zhiwen;Wang Ye;Meng Fanling;Luo Liang Nature Communications 2022,

[3]

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles[J] Jia Liang;Li Xin;Liu Hui;Xia Jindong;Shi Xiangyang;Shen Mingwu Nano Today 2021,

[4]

Dual-Mode Avocado-like All-Iron Nanoplatform for Enhanced T1/T2 MRI-Guided Cancer Theranostic Therapy.[J] Li Jing;Li Xincong;Gong Siman;Zhang Cuiting;Qian Chenggen;Qiao Hongzhi;Sun Minjie Nano letters 2020,

[5]

Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging and Chemotherapy.[J] Shen Zheyu;Chen Tianxiang;Ma Xuehua;Ren Wenzhi;Zhou Zijian;Zhu Guizhi;Zhang Ariel;Liu Yijing;Song Jibin;Li Zihou;Ruan Huimin;Fan Wenpei;Lin Lisen;Munasinghe Jeeva;Chen Xiaoyuan;Wu Aiguo ACS nano 2017,

[6]

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.[J] Ni Dalong;Bu Wenbo;Ehlerding Emily B;Cai Weibo;Shi Jianlin Chemical Society reviews 2017,

[7]

Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis.[J] Yuan Yue;Ding Zhanling;Qian Junchao;Zhang Jia;Xu Jinyong;Dong Xuejiao;Han Tao;Ge Shuchao;Luo Yufeng;Wang Yuwei;Zhong Kai;Liang Gaolin Nano letters 2016,

[8]

Biomimetic and Bioinspired Synthesis of Nanomaterials/Nanostructures.[J] Zan Guangtao;Wu Qingsheng Advanced materials (Deerfield Beach; Fla.) 2016,

[9]

Programmable materials and the nature of the DNA bond[J] Matthew R. Jones;Nadrian C. Seeman;Chad A. Mirkin Science 2015,

[10]

Towards polymetallic lanthanide complexes as dual contrast agents for magnetic resonance and optical imaging.[J] Debroye Elke;Parac-Vogt Tatjana N Chemical Society reviews 2014,

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