Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome

被引:0
作者
Mingjun Xu [1 ]
Xiaobo Hu [2 ]
Lin Wang [1 ]
Wei Zhang [1 ]
Lindi Wu [1 ]
Jifu Li [1 ]
Yuguo Chen [1 ]
Pengfei Zhang [1 ]
Haijun Su [3 ]
Yaling Han [4 ]
Cheng Zhang [1 ]
Mei Zhang [1 ]
Yun Zhang [1 ]
机构
[1] The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiova
[2] Department of Intensive Care Unit, Shandong Provincial Hospital affiliated to Shandong University
[3] School of Mathematics, Shandong University
[4] Department of Cardiology, Shenyang Military Region General Hospital
关键词
plasma biomarker; plaque strain; GRACE score; cardiovascular events; acute coronary syndrome;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
To test whether circulating and intracoronary biomarkers and coronary plaque strain have additive values to Global Registry of Acute Coronary Events(GRACE) score for predicting long-term cardiovascular events in ACS patients. One hundred ACS patients were enrolled and the GRACE score and plasma levels and intracoronary gradients of a number of biomarkers were measured. Coronary plaque burden and morphology in non-critical stenotic plaques were determined by intravascular ultrasound(IVUS) technique, and the maximal shear strain(SSmax) and maximal area strain(ASmax) were determined by intravascular ultrasound elastography(IVUSE) technique. Patients were followed for cardiovascular events and the predictive values of clinical characteristics, plasma biomarkers and plaque parameters were compared with GRACE score, and the incremental values of these measurements to the GRACE score were assessed. GRACE score, plasma biomarkers and plaque strain were independent predictors of cardiovascular events. Combination of GRACE score, plasma biomarkers and plaque strains significantly improved the predictive value of the GRACE score alone with the receiver-operating characteristic area increased from0.457 to 0.667(P=0.014). The combination of circulating and intracoronary biomarkers, plaque strain and GRACE score provides a better predictive tool than GRACE score alone in patients with ACS.
引用
收藏
页码:269 / 278
页数:10
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