Alpha-synuclein in mitochondrial dysfunction: opportunities or obstacles

被引：0
|
作者：
Shermali Gunawardena
机构：
[1] Department of Biological Sciences
[2] The State University of New York at Buffalo
来源：
Neural Regeneration Research | 2025年 / 20卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R741 [神经病学];
学科分类号：
摘要：
Recent work suggests a link between α-synuclein(α-syn) and mitochondrial dysfunction; however, the mechanisms of how α-syn influences mitochondrial function are still unclear. Most notably, whether α-syn plays a direct role during mitochondrial function and/or whether diseased α-syn-mediated mitochondrial dysfunction is a potential modifiable risk factor in Parkinson’s disease(PD) is unknown.
引用
收藏
页码：197 / 198
页数：2
相关论文
共 50 条
  • [1] Alpha-synuclein in mitochondrial dysfunction: opportunities or obstacles
    Gunawardena, Shermali
    NEURAL REGENERATION RESEARCH, 2025, 20 (01) : 197 - 198
  • [2] Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson Disease
    Dolgacheva, L. P.
    Fedotova, E. I.
    Abramov, A. Y.
    Berezhnov, A. V.
    BIOLOGICHESKIE MEMBRANY, 2017, 34 (05): : 4 - 14
  • [3] Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
    Esteves, A. R.
    Arduino, D. M.
    Silva, D. F. F.
    Oliveira, C. R.
    Cardoso, S. M.
    PARKINSONS DISEASE, 2011, 2011
  • [4] Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
    Dolgacheva L.P.
    Fedotova E.I.
    Abramov A.Y.
    Berezhnov A.V.
    Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2018, 12 (1) : 10 - 19
  • [5] Alpha-Synuclein Therapeutic Opportunities
    Trojanowski, J.
    MOVEMENT DISORDERS, 2010, 25 : S606 - S606
  • [6] Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
    Choi, Minee L.
    Yao, Zhi
    Tosatto, Laura
    Klenerman, David
    Abramov, Andrey Y.
    Gandhi, Sonia
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 471A - 471A
  • [7] Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
    Shavali, Shaik
    Brown-Borg, Holly M.
    Ebadi, Manuchair
    Porter, James
    NEUROSCIENCE LETTERS, 2008, 439 (02) : 125 - 128
  • [8] Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease
    Rocha, Emily M.
    De Miranda, Briana
    Sanders, Laurie H.
    NEUROBIOLOGY OF DISEASE, 2018, 109 : 249 - 257
  • [9] MITOCHONDRIAL DYSFUNCTION, OXIDATIVE STRESS AND ALPHA-SYNUCLEIN IN PARKINSON'S DISEASE
    Bandres, S.
    Duran, R.
    Barrero, F. J.
    Pelegrina, J.
    Ramirez, M.
    Vives, F.
    ACTA PHYSIOLOGICA, 2014, 212 : 76 - 76
  • [10] The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease
    Li, Hong-Yan
    Liu, De-Shui
    Zhang, Ying-Bo
    Rong, Hua
    Zhang, Xiao-Jie
    BIOPHYSICAL CHEMISTRY, 2023, 303
12345