Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

被引：0

作者：

Ze-chuan Yang ^{[1
,2
]}

Yan-chun Li ^{[3
]}

Fan Li ^{[2
]}

Qing-rong Huang ^{[4
]}

张国 ^{[1
]}

石彤非 ^{[2
]}

机构：

[1] Institute of Materials Science and Engineering, Jilin University

[2] State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences

[3] Department of Pediatric Respiratory Medicine, First Hospital of Jilin University

[4] Food Science Department, Cook College Rutgers University

来源：

Chinese Journal of Polymer Science | 2016年 / 34卷 / 03期

基金：

中国国家自然科学基金;

关键词：

pH-responsive; Hydrogel; Protein; Delivery;

D O I：

暂无

中图分类号：

O648.17 [凝胶及软胶]; TQ460.1 [基础理论];

学科分类号：

摘要：

New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives(curdlan-Bochistidine, CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L Na Cl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin(BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different p H values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

引用

页码：280 / 287

页数：8

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