Tuning beneficial calcineurin phosphatase activation to counter α-synuclein toxicity in a yeast model of Parkinson's disease

被引：0
|
作者：
Srishti Chawla [1 ,2 ]
Mikael Molin [2 ]
Thomas Nystrom [1 ]
机构：
[1] Institute for Biomedicine,Sahlgrenska Academy,Centre for Ageing and Health-Age Cap,University of Gothenburg
[2] Department of Life Sciences,Chalmers University of Technology
来源：
Neural Regeneration Research | 2025年 / 01期
关键词：
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中图分类号：
R742.5 [震颤麻痹综合征];
学科分类号：
1002 ;
摘要：
Calcineurin(CN) is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast, filamentous fungi, plants, and mammals. Its biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated T-cells. CN is a heterodimeric protein consisting of a catalytic subunit,
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页码：199 / 200
页数：2
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