miR-124在抑郁症中的作用机制

被引：2

作者：

薛燕 ^{[1
,2
]}

李德珠 ^{[1
]}

谢慧莹 ^{[1
,2
]}

蒋传邈 ^{[1
]}

张俊芳 ^{[1
,2
]}

机构：

[1] 宁波大学医学部,浙江省病理生理学技术研究重点实验室

[2] 宁波大学附属康宁医院

来源：

生物化学与生物物理进展 | 2024年 / 51卷 / 06期

基金：

浙江省自然科学基金;

关键词：

抑郁症; miR-124; 海马; 糖皮质激素受体; 神经发生; 神经炎症;

D O I：

10.16476/j.pibb.2023.0334

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

抑郁症是世界范围内最常见的精神疾病之一，发病机制复杂，研究仍处于探索阶段。微RNA (miRNA)作为表观遗传机制的重要调控因子，在抑郁症的发生发展中起着重要作用。miR-124是神经系统中表达最丰富的miRNA之一，参与了神经元分化、小胶质细胞激活等生物事件。近年研究表明，miR-124在抑郁症患者和动物模型中表达异常，并参与了病理生理机制。然而，miR-124的表达异常情况及其相关机制的研究结果是较复杂的、甚至矛盾的。故本文对此进行梳理，总结了miR-124在抑郁症中的研究进展。

引用

页码：1316 / 1326

页数：11

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