RADIOIMMUNODETECTION OF HUMAN SMALL-CELL LUNG-CARCINOMA XENOGRAFTS IN THE NUDE RAT USING IN-111 LABELED MONOCLONAL-ANTIBODY MOC-31

被引：11
作者：
DEJONGE, MWA
KOSTERINK, JGW
BIN, YY
BULTE, JWM
KENGEN, RAM
PIERS, DA
THE, TH
DELEIJ, L
机构：
[1] UNIV HOSP GRONINGEN,DEPT NUCL MED,GRONINGEN,NETHERLANDS
[2] UNIV HOSP GRONINGEN,DEPT PHARM,GRONINGEN,NETHERLANDS
[3] CHINA JAPAN FRIENDSHIP HOSP,INST MED RES,DEPT BIOCHEM & IMMUNOL,BEIJING,PEOPLES R CHINA
来源：
EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 13期
关键词：
D O I：
10.1016/0959-8049(93)90543-O
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pan-carcinoma membrane antigen. [In-111]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.
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收藏
页码：1885 / 1890
页数：6
相关论文
共 31 条
  • [11] DESHPANDE SV, 1990, J NUCL MED, V31, P218
  • [12] EARY JF, 1990, J NUCL MED, V31, P1257
  • [13] EPSTEIN AL, 1988, CANCER RES, V48, P5842
  • [14] ISOLATION OF PURE IGG1, IGG2A AND IGG2B IMMUNOGLOBULINS FROM MOUSE SERUM USING PROTEIN A-SEPHAROSE
    EY, PL
    PROWSE, SJ
    JENKIN, CR
    [J]. IMMUNOCHEMISTRY, 1978, 15 (07): : 429 - 436
  • [15] GOLDENBERG DM, 1988, ARCH PATHOL LAB MED, V112, P580
  • [16] EFFICIENT SELECTION OF HUMAN-TUMOR GROWTH-INHIBITING MONOCLONAL-ANTIBODIES
    HERLYN, D
    HERLYN, M
    ROSS, AH
    ERNST, C
    ATKINSON, B
    KOPROWSKI, H
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 73 (01) : 157 - 167
  • [17] RADIOACTIVE LABELING OF ANTIBODY - A SIMPLE AND EFFICIENT METHOD
    HNATOWICH, DJ
    LAYNE, WW
    CHILDS, RL
    LANTEIGNE, D
    DAVIS, MA
    GRIFFIN, TW
    DOHERTY, PW
    [J]. SCIENCE, 1983, 220 (4597) : 613 - 615
  • [18] IANUZZI MC, 1986, AM REV RESPIR DIS, V134, P593
  • [19] JAIN RK, 1990, CANCER RES, V50, pS814
  • [20] JONES PL, 1990, CANCER RES, V50, pS852
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