IMMUNOHISTOCHEMICAL DETECTION OF SUBSTANCE-P AND VASOACTIVE-INTESTINAL-PEPTIDE FIBERS IN THE AURICULAR LYMPH-NODES OF SENSITIZED GUINEA-PIGS AND MICE

被引：2

作者：

ENZMANN, V

DROSSLER, K

机构：

[1] Department of Biosciences, University of Leipzig, Leipzig, 04103

来源：

ACTA HISTOCHEMICA | 1994年 / 96卷 / 01期

关键词：

SUBSTANCE P; VASOACTIVE INTESTINAL PEPTIDE; LYMPHOID ORGANS; NERVE FIBERS; GUINEA PIGS; MOUSE;

D O I：

10.1016/S0065-1281(11)80004-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The presence of substance P (SP) and vasoactive intestinal peptid (VIP) in auricular lymph nodes of normal and sensitized guinea pigs and mice has been investigated using polyclonal antibodies directed against these neurotransmitters and the unlabelled peroxidase-antiperoxidase procedure. Positive immunoreactivity could be observed only in draining lymph nodes of sensitized animals. SP-immunoreactivity was found in mice and guinea pigs but a VIP-positive reaction only in mice. The immunopositive sites were always associated with blood vessels. The present study suggests that the neurotransmitters SP and VIP are involved in mechanisms of sensitization taking place in secondary lymphoid organs.

引用

页码：15 / 18

页数：4

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