A CORRELATION OF ARGYROPHILIC NUCLEOLAR ORGANIZER REGIONS WITH PROGNOSES IN PATIENTS WITH MAXILLARY SINUS SQUAMOUS-CELL CARCINOMA

被引：4

作者：

MIYAGUCHI, M ^{[1
]}

KAWAHARA, T ^{[1
]}

SAKAI, S ^{[1
]}

KUWABARA, H ^{[1
]}

SAKAMOTO, H ^{[1
]}

机构：

[1] KAGAWA UNIV,SCH MED,DEPT PATHOL 2,MIKI,KAGAWA 76107,JAPAN

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1994年 / 251卷 / 04期

关键词：

CELL ARGYROPHILIC NUCLEOLAR ORGANIZER REGION; MAXILLARY SINUS CARCINOMA; METASTASIS; LOCAL RECURRENCE; EPIDERMAL GROWTH FACTOR RECEPTOR;

D O I：

10.1007/BF00628429

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Argyrophilic nucleolar organizer regions (AgNORs) were determined by a semiautomatic image analyzer in a group of 28 patients with T2 or T3 maxillary sinus squamous cell carcinoma. The group was separated into recurrent and non-recurrent groups, metastatic and non-metastatic groups, as well as groups strongly or weakly positive for epidermal growth factor receptor (EGFR). The mean number and area of AgNOR dots per nucleus and the mean size of each dot were calculated. The mean number and area were significantly greater than those in normal cells (P < 0.001), but not in recurrent and non-recurrent groups, metastatic and non-metastatic groups and groups separated by EGFR. There was also no difference found in the mean sizes of tumor and normal cells. These results suggest that AgNOR is related to malignant transformation, but not prognosis.

引用

页码：229 / 232

页数：4