LUMINOL ENHANCED CHEMILUMINESCENCE OF THE PERFUSED RAT-HEART DURING ISCHEMIA AND REPERFUSION

被引：33
|
作者：
KUMAR, C [1 ]
OKUDA, M [1 ]
IKAI, I [1 ]
CHANCE, B [1 ]
机构：
[1] UNIV CITY SCI CTR,PHILADELPHIA,PA 19104
来源：
FEBS LETTERS | 1990年 / 272卷 / 1-2期
关键词：
Chemiluminescence; Heart; Ischemia; Luminol; Reperfusion;
D O I：
10.1016/0014-5793(90)80463-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We show that the production of Luminol reactive oxygen radicals in the perfused rat heart under ischemia and reperfusion can be monitored continuously by measuring the chemiluminescence of Luminol-perfused hearts. Luminol did not affect the monitored physiological parameters of the hearts. Chemiluminescence increased during ischemia and reperfusion. Superoxide dismutase treatment of the heart before ischemia, but not catalase, abolished these increases. © 1990.
引用
收藏
页码：121 / 124
页数：4
相关论文
共 50 条
  • [31] GLYCOLYTIC ENZYME IN RESPONSE TO ANOXIA AND ISCHEMIA IN PERFUSED RAT-HEART AND SHEEP HEART
    MORTON, DJ
    CLARKE, FM
    HAMILTON, D
    HUXHAM, G
    PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 1979, 12 : 46 - 46
  • [32] BENEFICIAL EFFECT OF MAGNESIUM ON THE ISOLATED PERFUSED RAT-HEART DURING REPERFUSION AFTER ISCHEMIA - COMPARISON BETWEEN PREISCHEMIC AND POSTISCHEMIC ADMINISTRATION OF MAGNESIUM
    HARA, A
    MATSUMURA, H
    ABIKO, Y
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1990, 342 (01) : 100 - 106
  • [33] EFFECT OF PYRUVATE ON RAT-HEART THIOL STATUS DURING ISCHEMIA AND HYPOXIA FOLLOWED BY REPERFUSION
    RIGOBELLO, MP
    BINDOLI, A
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1993, 122 (02) : 93 - 100
  • [34] AUTORADIOGRAPHIC EVALUATION OF GLUCOSE-UPTAKE IN THE RAT-HEART DURING REGIONAL ISCHEMIA AND REPERFUSION
    KAGAYA, Y
    MIURA, Y
    ISHIDE, N
    MARUYAMA, Y
    INOOKA, E
    TAKISHIMA, T
    IDO, T
    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1984, 48 (08): : 881 - 881
  • [35] INOSITOL PHOSPHATE RELEASE AND METABOLISM DURING MYOCARDIAL-ISCHEMIA AND REPERFUSION IN RAT-HEART
    ANDERSON, KE
    DART, AM
    WOODCOCK, EA
    CIRCULATION RESEARCH, 1995, 76 (02) : 261 - 268
  • [36] THE RESPONSE TO ISCHEMIA IN BLOOD PERFUSED VS CRYSTALLOID PERFUSED ISOLATED RAT-HEART PREPARATIONS
    WALTERS, HL
    DIGERNESS, SB
    NAFTEL, DC
    WAGGONER, JR
    BLACKSTONE, EH
    KIRKLIN, JW
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992, 24 (10) : 1063 - 1077
  • [37] REPERFUSION FOLLOWING MYOCARDIAL-ISCHEMIA ENHANCES INOSITOL PHOSPHATE RELEASE IN THE ISOLATED-PERFUSED RAT-HEART
    ANDERSON, KE
    DART, AM
    WOODCOCK, EA
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1994, 21 (02) : 141 - 144
  • [38] ISCHEMIA-REPERFUSION INDUCED ARRHYTHMIAS IN THE ISOLATED RAT-HEART
    VANGILST, WH
    DELANGEN, CDJ
    PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1982, 4 (05) : 160 - 160
  • [39] PROTECTIVE EFFECTS OF AN ADENOSINE-DEAMINASE INHIBITOR ON ISCHEMIA-REPERFUSION INJURY IN ISOLATED PERFUSED RAT-HEART
    ZHU, QY
    CHEN, SG
    ZOU, CM
    AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03): : H835 - H838
  • [40] EFFECT OF ISCHEMIA (I) AND REPERFUSION (R) ON MITOCHONDRIAL INNER MEMBRANE (MIM) PROTEINS IN THE ISOLATED PERFUSED RAT-HEART
    ARDUINI, A
    MEZZETTI, A
    LAPENNA, D
    PORRECA, E
    DEJULIA, J
    DECESARE, M
    CUCCURULLO, F
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1986, 18 : 10 - 10
12345