BENZOTRIAZOLE-ASSISTED SYNTHESIS OF NOVEL MANNICH-BASES FROM KETONES AND DIVERSE ALDEHYDES

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde. © 1990.