ENZYME-INDUCTION AND INHIBITION

被引：67
作者：
BARRY, M [1 ]
FEELY, J [1 ]
机构：
[1] ST JAMES HOSP, TRINITY COLL, SCH MED, DEPT PHARMACOL & THERAPEUT, DUBLIN 8, IRELAND
来源：
PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 01期
关键词：
D O I：
10.1016/0163-7258(90)90019-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme system. Similarly a wide range of drugs may produce clinically significant drug interactions following enzyme inhibition. Assessment of enzyme induction and inhibition in man involves diverse methods including the use of model drugs. © 1990.
引用
收藏
页码：71 / 94
页数：24
相关论文
共 267 条
[101]   INHIBITION OF HUMAN-LIVER CYTOCHROME-P-450 BY OMEPRAZOLE [J].
JENSEN, JC ;
GUGLER, R .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 21 (03) :328-330
[102]   CHANGES OF SMOOTH ENDOPLASMIC-RETICULUM INDUCED BY RIFAMPICIN IN HUMAN AND GUINEA-PIG HEPATOCYTES [J].
JEZEQUEL, AM ;
TENCONI, LT ;
ORLANDI, F .
GUT, 1971, 12 (12) :984-&
[103]  
JOHNSEN SG, 1976, CLIN PHARMACOL THER, V20, P233
[104]  
JONES PBC, 1986, J BIOL CHEM, V261, P6647
[105]   WARFARIN AND DISTALGESIC INTERACTION [J].
JONES, RV .
BRITISH MEDICAL JOURNAL, 1976, 1 (6007) :460-460
[106]   EFFECT OF DIPHENYLHYDANTOIN ON METABOLISM OF DEXAMETHASONE - MECHANISM OF ABNORMAL DEXAMETHASONE SUPPRESSION IN HUMANS [J].
JUBIZ, W ;
MEIKLE, AW ;
LEVINSON, RA ;
MIZUTANI, S ;
WEST, CD ;
TYLER, FH .
NEW ENGLAND JOURNAL OF MEDICINE, 1970, 283 (01) :11-&
[107]   ROLE OF TOBACCO SMOKING IN PHARMACOKINETICS [J].
JUSKO, WJ .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1978, 6 (01) :7-39
[108]   PHENACETIN O-DEETHYLASE - AN ACTIVITY OF A CYTOCHROME-P-450 SHOWING GENETIC-LINKAGE WITH THAT CATALYZING THE 4-HYDROXYLATION OF DEBRISOQUINE [J].
KAHN, GC ;
BOOBIS, AR ;
BRODIE, MJ ;
TOVERUD, EL ;
MURRAY, S ;
DAVIES, DS .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 20 (01) :67-76
[109]  
KAPPAS A, 1978, CLIN PHARMACOL THER, V23, P445
[110]   INCREASED RATE OF TOLBUTAMIDE METABOLISM IN ALCOHOLIC PATIENTS [J].
KATER, RMH ;
TOBON, F ;
IBER, FL .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1969, 207 (02) :363-&
6789101112131415