ENZYME-INDUCTION AND INHIBITION

被引：67
作者：
BARRY, M [1 ]
FEELY, J [1 ]
机构：
[1] ST JAMES HOSP, TRINITY COLL, SCH MED, DEPT PHARMACOL & THERAPEUT, DUBLIN 8, IRELAND
来源：
PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 01期
关键词：
D O I：
10.1016/0163-7258(90)90019-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme system. Similarly a wide range of drugs may produce clinically significant drug interactions following enzyme inhibition. Assessment of enzyme induction and inhibition in man involves diverse methods including the use of model drugs. © 1990.
引用
收藏
页码：71 / 94
页数：24
相关论文
共 267 条
[1]   EVIDENCE FOR FUNCTION OF D-GLUCARIC ACID AS AN INDICATOR FOR DRUG INDUCED ENHANCED METABOLISM THROUGH GLUCURONIC ACID PATHWAY IN MAN [J].
AARTS, EM .
BIOCHEMICAL PHARMACOLOGY, 1965, 14 (03) :359-&
[2]  
ACOCELLA G, 1978, PHARMACOL RES COMMUN, V10, P271
[3]   KINETIC STUDIES ON RIFAMPICIN .1. SERUM CONCENTRATION ANALYSIS IN SUBJECTS TREATED WITH DIFFERENT ORAL DOSES OVER A PERIOD OF 2 WEEKS [J].
ACOCELLA, G ;
BARONI, GC ;
MARCHETTI, M ;
PAGANI, V ;
NICOLIS, FB .
CHEMOTHERAPY, 1971, 16 (06) :356-+
[4]  
ADESNIK M, 1981, J BIOL CHEM, V256, P340
[5]  
ANDERS MW, 1966, MOL PHARMACOL, V2, P319
[6]   NUTRITION AND OXIDATIVE DRUG-METABOLISM IN MAN - RELATIVE INFLUENCE OF DIETARY LIPIDS, CARBOHYDRATE, AND PROTEIN [J].
ANDERSON, KE ;
CONNEY, AH ;
KAPPAS, A .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1979, 26 (04) :493-501
[7]   INFLUENCES OF DIET AND NUTRITION ON CLINICAL PHARMACOKINETICS [J].
ANDERSON, KE .
CLINICAL PHARMACOKINETICS, 1988, 14 (06) :325-346
[8]  
ANTHINTZ MA, 1968, CURR THER RES, V10, P70
[9]   RECEPTORS - FROM FICTION TO FACT [J].
ARIENS, EJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1979, 1 (01) :11-15
[10]   EFFECT OF RIFAMPICIN ON NORETHISTERONE PHARMACOKINETICS [J].
BACK, DJ ;
BRECKENRIDGE, AM ;
CRAWFORD, F ;
MACIVER, M ;
ORME, ML ;
PARK, BK ;
ROWE, PH ;
SMITH, E .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 15 (03) :193-197
12345678910