COMPARISON OF CEFPODOXIME PROXETIL WITH CEFACLOR IN THE TREATMENT OF SINUSITIS

被引：24
|
作者：
GEHANNO, P
DEPONDT, J
BARRY, B
SIMONET, M
DEWEVER, H
机构：
[1] HOP NECKER ENFANTS MALAD,F-75730 PARIS 15,FRANCE
[2] HOP UNIV ST PIERRE,B-1000 BRUSSELS,BELGIUM
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1990年 / 26卷
关键词：
D O I：
10.1093/jac/26.suppl_E.87
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The efficacy and tolerance of cefpodoxime proxetil were compared with those of cefaclor in a multicentre, international, prospective, double-blind, placebocontrolled study in adult outpatients suffering from acute sinusitis. At the end of treatment, cefpodoxime proxetil was more effective than cefaclor, producing complete clinical cure in 84% of cases (102/122) vs 68% of cases (77/114) in the cefaclor group (P = 0.01). The overall clinical efficacy (cure + improvement) was similar in the two groups with 95% (116/122) satisfactory responses in the cefpodoxime proxetil group and 93% (106/114) in the cefaclor group. Bacteriological response was similar with 95% eradication in the cefpodoxime proxetil group (55/58) vs 91% with cefaclor (63/69). © 1990 The British Society for Antimicrobial Chemotherapy.
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页码：87 / 91
页数：5
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