CDC2 REGULATORY FACTORS

被引：333
作者：
COLEMAN, TR
DUNPHY, WG
机构：
[1] Howard Hughes Medical Institute, Division of Biology 216-76, California Institute of Technology, Pasadena
来源：
CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 06期
关键词：
D O I：
10.1016/0955-0674(94)90060-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A growing family of kinases and phosphatases controls the activity of the cyclin-dependent kinase cdc2. The past year has seen the identification of the cdk activating kinase as well as considerable elucidation of the cdc25/wee1 regulatory pathways. Both cdc25 and wee1 appear to be regulated by upstream kinase/phosphatase networks. In addition, it is likely that other regulatory mechanisms cooperate with the wee1/cdc25 phosphorylation systems to control the action of cdc2. Together, these elaborate checks and balances ensure that cdc2 triggers mitosis at the appropriate time.
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收藏
页码：877 / 882
页数：6
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