KINETICS OF PHENOLS IN BODY-FLUID COMPARTMENTS DURING HEMODIALYSIS

被引：1

作者：

ERBEN, J ^{[1
]}

SCHUCK, O ^{[1
]}

BRATOVA, M ^{[1
]}

MOUCKA, P ^{[1
]}

PALICKA, V ^{[1
]}

FIXA, P ^{[1
]}

HAJKOVA, B ^{[1
]}

HEROUT, V ^{[1
]}

STILEC, R ^{[1
]}

ZAHRADNIK, J ^{[1
]}

机构：

[1] INST CLIN & EXPTL MED,PRAGUE,CZECH REPUBLIC

来源：

ARTIFICIAL ORGANS | 1995年 / 19卷 / 06期

关键词：

DIRECT DIALYSIS QUANTIFICATION; FREE PHENOLS; GENERATION RATE OF PHENOLS; DIALYSIS CLEARANCE OF PHENOLS;

D O I：

10.1111/j.1525-1594.1995.tb02375.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

On the basis of direct quantification of hemodialysis (HD), the kinetics of phenols (Ph) were followed in 13 patients on regular HD treatment. The average plasma levels of Ph before and after HD were 627 +/- 109 mu mol/L and 416 +/- 81 mu mol/L, respectively. The total amount of Ph removed during 5-h HD was 7,481 +/- 1,894 mu mol. For calculation of the generation rate (G), a new formula has been derived not requiring knowledge of the corresponding volume of distribution. The G of Ph was 2.9 +/- 0.7 mu mol/min on average. The mean dialysis clearance (K) of Ph was 48.2 1 10.2 ml/min.

引用

页码：544 / 546

页数：3

共 7 条

[1]

Jutzler GA, Kramer HJ, Keller HE, Doenecke F., Zum Ver‐halten der Phenole und des Kreatinins bei Niereninsuffiziens, insbesondere bei chronischen Dialysepatienten, Arch Klin Med, 214, pp. 214-219, (1968)

[2]

Molinas FC., Inhibition by phenol and phenolic acids of plate release reaction, Thromb Diath Hemorrh, 30, pp. 334-348, (1973)

[3]

Langhorst BJ, Ellis P, Nosse C, Et al., A practical guide to kinetic modeling by direct analysis quantification, Dial Transplant, 12, (1983)

[4]

Niwa T., Phenol and p‐cresol accumulated in uremic serum measured by HPLC with fluorescence detection, Clin Chem, 39, pp. 108-111, (1993)

[5]

Erben J, Bratova M, Zahradnik J., pp. 157-160, (1985)

[6]

Malchevsky PS, Ellis P, Nosse C, Et al., Direct quantification of dialysis, Dial Transplant, 11, pp. 42-44, (1983)

[7]

Folin O, Ciocalta UV., Method for phenol determination, J Biol Chem, 74, pp. 627-629, (1927)

← 1 →