PROTECTION AGAINST ISCHEMIC HIPPOCAMPAL CA1 DAMAGE IN THE RAT WITH A NEW NON-NMDA ANTAGONIST, NBQX

被引：113

作者：

DIEMER, NH ^{[1
]}

JORGENSEN, MB ^{[1
]}

JOHANSEN, FF ^{[1
]}

SHEARDOWN, M ^{[1
]}

HONORE, T ^{[1
]}

机构：

[1] NOVO NORDISK,DIV CNS,SOBORG,DENMARK

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 86卷 / 01期

关键词：

D O I：

10.1111/j.1600-0404.1992.tb08052.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two glutamate antagonists were tested in a rat model of complete, transient cerebral ischemia. Six days after 10 min ischemia the mean loss of hippocampal CA1 pyramidal neurones was 73%. Administration of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid) antagonist NBQX (2,3-dihydro-6-nitro-7-sulfamoyl-benzo(F)quinoxaline) reduced the pyramidal neurone loss to 1%, 11% and 15%, when given before, immediately after or 1 h after ischemia, respectively. MK-801 (dizocilpine), a competitive NMDA antagonist gave no protection in this model. We suggest that the AMPA receptor transduction mechanisms are sensitized by ischemia and that the postischemic blockade of the main glutamatergic input to the CA1 cells with NBQX impairs the deleterious effect of "normal" postischemic excitatory transmission.

引用

页码：45 / 49

页数：5

共 36 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].