SEQUENCES ON THE N-TERMINUS OF ACH RECEPTOR SUBUNITS REGULATE THEIR ASSEMBLY

被引：28
|
作者：
SUMIKAWA, K
机构：
[1] Department of Psychobiology, University of California, Irvine
来源：
MOLECULAR BRAIN RESEARCH | 1992年 / 13卷 / 04期
关键词：
ACETYLCHOLINE RECEPTOR; TORPEDO; XENOPUS-OOCYTE; SUBUNIT ASSEMBLY; SITE-DIRECTED MUTAGENESIS; ASSEMBLY SIGNAL; CHIMERIC RECEPTOR SUBUNIT;
D O I：
10.1016/0169-328X(92)90218-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mutant a subunits of Torpedo acetylcholine receptors (AChR) were constructed and expressed in Xenopus oocytes together with other normal subunits to investigate regions in the subunit that are required for subunit assembly. I have found that chimeric-alpha-subunits, consisting of the N-terminal extracellular domain of the AChR alpha-subunit, followed either by the hydrophobic transmembrane segments of GABA(A) receptor or glutamate receptor subunits, were still recognized as the AChR subunit and associated with co-expressed other normal AChR subunits, suggesting that this part of the N-terminal extracellular domain contains 'assembly signals'.
引用
收藏
页码：349 / 353
页数：5
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