THE PENETRATION OF CEFPIROME INTO THE POTENTIAL SITES OF PULMONARY INFECTION

被引：36

作者：

BALDWIN, DR ^{[1
]}

MAXWELL, SRJ ^{[1
]}

HONEYBOURNE, D ^{[1
]}

ANDREWS, JM ^{[1
]}

ASHBY, JP ^{[1
]}

WISE, R ^{[1
]}

机构：

[1] DUDLEY RD GEN HOSP,DEPT MED MICROBIOL,BIRMINGHAM B18 7QH,W MIDLANDS,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1991年 / 28卷 / 01期

关键词：

D O I：

10.1093/jac/28.1.79

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The concentrations of cefpirome, a new semi-synthetic cephalosponn, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed epithelial lining fluid (ELF) concentrations to be measured in eight subjects. The mean concentration for serum was 34.5 mg/L (S.E.M. 3.3), for bronchial mucosa 19.3 mg/kg (S.E.M. 1.9) and for ELF 7.2 mg/L (S.E.M. 1.1). The progressive reduction in cefpirome concentration in serum compared to that in bronchial mucosa and ELF is consistent with the permeability characteristics of β-lactam antimicrobials and the barriers to movement of antimicrobial agents present in the lung. © 1991, by The British Society for Antimicrobial Chemotherapy.

引用

页码：79 / 86

页数：8

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