SEQUENCE-ANALYSIS OF PEPTIDES BOUND TO MHC CLASS-II MOLECULES

被引：1014
作者：
RUDENSKY, AY
PRESTONHURLBURT, P
HONG, SC
BARLOW, A
JANEWAY, CA
机构：
[1] YALE UNIV,SCH MED,PSYCHOL SECT,NEW HAVEN,CT 06510
[2] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510
来源：
NATURE | 1991年 / 353卷 / 6345期
关键词：
D O I：
10.1038/353622a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
CD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules of the major histocompatibility complex (MHC). Naturally processed peptide fragments bound to MHC class II molecules are peptides of 13-17 amino acids which appear to be precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II molecule. The finding of predominant self peptides has interesting implications for antigen processing and self-non-self discrimination.
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收藏
页码：622 / 627
页数：6
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