FEEDBACK-REGULATION OF 3-HYDROXY-3-METHYGLUTARYL COENZYME A REDUCTASE IN LIVERS OF MICE TREATED WITH MEVINOLIN, A COMPETITIVE INHIBITOR OF THE REDUCTASE

被引：306

作者：

KITA, T ^{[1
]}

BROWN, MS ^{[1
]}

GOLDSTEIN, JL ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DALLAS,TX 75235

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1980年 / 66卷 / 05期

关键词：

D O I：

10.1172/JCI109938

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：1094 / 1100

页数：7

共 18 条

[1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2] 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE - REGULATION OF ENZYMATIC-ACTIVITY BY PHOSPHORYLATION AND DEPHOSPHORYLATION [J].

BEG, ZH ;

STONIK, JA ;

BREWER, HB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3678-3682

[3] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM [J].

BROWN, AG ;

SMALE, TC ;

KING, TJ ;

HASENKAMP, R ;

THOMPSON, RH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11) :1165-1173

[4] ROLE OF LOW-DENSITY LIPOPROTEIN RECEPTOR IN REGULATING CONTENT OF FREE AND ESTERIFIED CHOLESTEROL IN HUMAN FIBROBLASTS [J].

BROWN, MS ;

FAUST, JR ;

GOLDSTEIN, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (04) :783-793

[5]

BROWN MS, 1979, J BIOL CHEM, V254, P5144

[6]

BROWN MS, 1978, J BIOL CHEM, V253, P1121

[7]

BROWN MS, 1980, J LIPID RES, V21, P505

[8]

EDWARDS PA, 1977, J BIOL CHEM, V252, P1057

[9] COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY [J].

ENDO, A ;

KURODA, M ;

TANZAWA, K .

FEBS LETTERS, 1976, 72 (02) :323-326

[10] MONACOLIN-K, A NEW HYPOCHOLESTEROLEMIC AGENT PRODUCED BY A MONASCUS SPECIES [J].

ENDO, A .

JOURNAL OF ANTIBIOTICS, 1979, 32 (08) :852-854

← 1 2 →