The Effect of Intravenous Magnesium Sulfate on Post-Operative Analgesia During Laminectomy

被引:15
作者
Ghaffaripour, Sina [1 ]
Mahmoudi, Hilda [2 ]
Eghbal, Hossein [1 ]
Rahimi, Ashkan [1 ]
机构
[1] Shiraz Univ Med Sci, Dept Anesthesiol, Shiraz Anesthesiol & Crit Care Res Ctr, Shiraz, Iran
[2] Aventura Hosp & Med Ctr, GME, Aventura, FL 33180 USA
来源
CUREUS | 2016年 / 8卷 / 06期
关键词
magnesium sulfate; laminectomy; patient controlled analgesia; pca; analgesia; pain management;
D O I
10.7759/cureus.626
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Post-operative pain control is an important concern for both patients and physicians. Magnesium is being used as an adjuvant for anesthesia and analgesia during and after various surgeries. We aimed to investigate the effects of intravenous magnesium sulfate on postoperative analgesia after laminectomy. Methods Materials: In this randomized double-blind controlled clinical trial, we enrolled 40 adult patients aged 1860 with American Society of Anesthesiologists (ASA) Class I-II who were candidates for elective laminectomy. The patients were randomly assigned in two control groups and were similarly anesthetized. In the case group, after the induction of anesthesia, a loading dose of magnesium sulfate (30 mg/kg) was administered within five to 10 minutes followed by a maintenance dose of 10 mg/kg/hr up to the end of the surgery; while, the patients in the control group received the same volume of saline. After the surgery, all patients received a patient-controlled intravenous analgesia (PCA) pump containing morphine. The first time of using PCA, the amount of consumed morphine during the first 24 hours, and pain score were recorded at 6,12,18 and 24 hours in the post-operative period. Results: There was no significant difference between the two groups with respect to the amount of morphine consumed in 24 hours after the surgery (P value =0.23), the first time of using of PCA pump (P value =0.79) and pain intensity (P value=0.52). Conclusion: The infusion of Magnesium Sulfate during laminectomy had no effect on patients' pain and opioid requirement during the first 24 hours after the surgery.
引用
收藏
页数:6
相关论文
共 22 条
[1]  
Abrishamkar S, 2011, J RES MED SCI, V16, P621
[2]  
Abrishamkar Saeid, 2010, Middle East Journal of Anesthesiology, V20, P839
[3]  
Akhtar MI, 2011, J PAK MED ASSOC, V61, P1220
[4]   Influence of ethnicity on the perception and treatment of early post-operative pain [J].
Al-Hashimi, Mhamad ;
Scott, Simon ;
Griffin-Teall, Nicola ;
Thompson, Jonathan .
BRITISH JOURNAL OF PAIN, 2015, 9 (03) :167-172
[5]   Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis [J].
Albrecht, E. ;
Kirkham, K. R. ;
Liu, S. S. ;
Brull, R. .
ANAESTHESIA, 2013, 68 (01) :79-90
[6]   Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy [J].
Bhatia, A ;
Kashyap, L ;
Pawar, DK ;
Trikha, A .
JOURNAL OF CLINICAL ANESTHESIA, 2004, 16 (04) :262-265
[7]   Epidural magnesium reduces postoperative analgesic requirement [J].
Bilir, A. ;
Gulec, S. ;
Erkan, A. ;
Ozcelik, A. .
BRITISH JOURNAL OF ANAESTHESIA, 2007, 98 (04) :519-523
[8]  
Callister LC, 2003, HOME HLTH CARE MANAG, V15, P207, DOI [10.1177/ 1084822302250687, DOI 10.1177/1084822302250687]
[9]   Ethnic differences in responses to multiple experimental pain stimuli [J].
Campbell, CM ;
Edward, RR ;
Fillingim, RB .
PAIN, 2005, 113 (1-2) :20-26
[10]   Intravenous magnesium sulfate for post-operative pain in patients undergoing lower limb orthopedic surgery [J].
Dabbagh, A. ;
Elyasi, H. ;
Razavi, S. S. ;
Fathi, M. ;
Rajaei, S. .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2009, 53 (08) :1088-1091