REVERSIBLE AND SELECTIVE ANTAGONISM BY SURAMIN OF ATP-ACTIVATED INWARD CURRENT IN PC12 PHEOCHROMOCYTOMA CELLS

被引：50
|
作者：
NAKAZAWA, K
FUJIMORI, K
TAKANAKA, A
INOUE, K
机构：
[1] Division of Pharmacology, Natl. Inst. Hygienic Sciences, Setagaya, Tokyo 158
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 01期
关键词：
D O I：
10.1111/j.1476-5381.1990.tb12117.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The effects of suramin on an adenosine 5'-triphosphate (ATP)-activated inward current were investigated in PC12 phaeochromocytoma cells with whole-cell voltage-clamp techniques. 2. Suramin (30 to 300 μM) inhibited the ATP-activated current in a dose-dependent manner. The inhibitory effects were reversible and competitive. 3. Suramin also suppressed the current activated by adenosine 5'-O-(3-thiotriphosphate) but did not affect the current activated by nicotine. Suramin did not affect the suppression of a K current induced by methacholine. 4. The results suggest that suramin antagonizes the ATP-receptor-operated membrane current reversibly and selectively.
引用
收藏
页码：224 / 226
页数：3
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