NON-RANDOM DISTRIBUTION OF CHROMOSOMAL-ABERRATIONS INDUCED BY 3 CHEMICALS

被引：54
作者：
MEYNE, J
LOCKHART, LH
ARRIGHI, FE
机构：
[1] UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST, CTR CANC, DEPT BIOL, HOUSTON, TX 77030 USA
[2] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, GALVESTON, TX 77550 USA
[3] UNIV TEXAS, MED BRANCH, DEPT HUMAN BIOL CHEM & GENET, GALVESTON, TX 77550 USA
来源：
MUTATION RESEARCH | 1979年 / 63卷 / 01期
关键词：
D O I：
10.1016/0027-5107(79)90116-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The G[Giemsa]-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosome arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that certain bands were susceptible to damage induced by all 3 chemicals; certain bands were resistant to damage by all 3 chemicals; certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.
引用
收藏
页码：201 / 209
页数：9
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