EVALUATION OF DEFICIENCY OF 21-HYDROXYLATION IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA

被引：8
作者：
GALAL, OM
RUDD, BT
DRAYER, NM
机构：
[1] Institute of Child Health, University of Birmingham
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 1968年 / 43卷 / 230期
关键词：
D O I：
10.1136/adc.43.230.410
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The measurement of urinary steroid metabolites before and after ACTH stimulation was used to determine the extent of the 21-hydroxylase defect present in the cortisol pathway of 18 patients with congenital adrenal hyperplasia, who were receiving steroid therapy. The results indicate that the degree of 21-hydroxylase deficiency in the cortisol pathway is directly related to the two clinical variants of the disease, salt-losing and non-salt-losing.
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页码：410 / &
相关论文
共 14 条
[1]   A SIMPLE METHOD FOR ANALYZING COMPLICATED ABSORPTION CURVES, OF USE IN THE COLORIMETRIC DETERMINATION OF URINARY STEROIDS [J].
ALLEN, WM .
JOURNAL OF CLINICAL ENDOCRINOLOGY, 1950, 10 (01) :71-83
[2]   ADRENOGENITAL SYNDROME [J].
BONGIOVANNI, AM ;
ROOT, AW .
NEW ENGLAND JOURNAL OF MEDICINE, 1963, 268 (25) :1391-+
[3]   ADRENOGENITAL SYNDROME [J].
BONGIOVANNI, AM ;
ROOT, AW .
NEW ENGLAND JOURNAL OF MEDICINE, 1963, 268 (24) :1342-&
[4]  
BONGIOVANNI AM, 1958, PEDIATRICS, V21, P661
[5]   ADRENOGENITAL SYNDROME [J].
BONGIOVANNI, AM ;
ROOT, AW .
NEW ENGLAND JOURNAL OF MEDICINE, 1963, 268 (23) :1283-&
[6]  
BUSH IE, 1961, CHROMATOGRAPHY STERO, P336
[7]   A NEW STAINING TECHNIQUE FOR KETOSTEROID CHROMATOGRAMS [J].
EPSTEIN, E ;
ZAK, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1963, 23 (04) :355-+
[8]   17ALPHA-HYDROXYPROGESTERONE - A SALT-LOSING STEROID - RELATION TO CONGENITAL ADRENAL HYPERPLLASIA [J].
JACOBS, DR ;
GABRILOVE, JL ;
SOFFER, LJ ;
VANDERPO.J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1961, 21 (08) :909-+
[9]   ALDOSTERONE SECRETION RATE IN CONGENITAL ADRENAL HYPERPLASIA . A DISCUSSION OF THEORIES ON PATHOGENESIS OF SALT-LOSING FORM OF SYNDROME [J].
KOWARSKI, A ;
FINKELSTEIN, JW ;
SPAULDING, JS ;
HOLMAN, GH ;
MIGEON, CJ .
JOURNAL OF CLINICAL INVESTIGATION, 1965, 44 (09) :1505-+
[10]   NEUE 16-ALPHA-HYDROXYSTEROIDE AUS MENSCHLICHEM URIN UND AUS SCHWEINE-NEBENNIEREN - ISOLIERUNG, KONSTITUTION, SYNTHESEN UBER STEROIDE .156. [J].
NEHER, R ;
MEYSTRE, C ;
WETTSTEIN, A .
HELVETICA CHIMICA ACTA, 1959, 42 (01) :132-152
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