Management of Recurrent or Metastatic Retroperitoneal Soft-Tissue Sarcomas

被引:0
|
作者
Damianov, D. [1 ]
Asenov, Y. [1 ]
Kurtev, P. [2 ]
Penkov, N. [1 ]
Korukov, B. [1 ]
Gerzilov, P. [1 ]
Sedloev, T. [1 ]
Golemanov, B. [3 ]
机构
[1] Univ Hosp Queen Joanna, Dept Surg, 8 Byalo More Str, Sofia 1527, Bulgaria
[2] Specialized Hosp Act Treatment Oncol, Dept Surg, Sofia, Bulgaria
[3] Univ Hosp Queen Joanna, Dept Gastroenterol, Sofia, Bulgaria
关键词
locally recurrent; metastatic; retroperitoneal soft-tissue sarcomas; resection; radiotherapy;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
Retroperitoneal soft-tissue sarcomas remain a serious therapeutic problem. The aim of the study is to define the optimal treatment strategy of patients with locally recurrent or metastatic retroperitoneal soft-tissue sarcomas. Material and methods: A retrospective study was performed. Between 2001 and 2013, 89 patients with retroperitoneal soft-tissue sarcomas were surgically treated in the University Hospital "Queen Joanna - ISUL" and the Specialized Hospital for Active Treatment in Oncology - Sofia. Clinicopathological data were investigated with SPSS-19. Results: The mean time of onset of the first and second relapse of sarcomas was 23 and 13 months, respectively. Over 40% of the studied patients underwent more than one operation because of recurrence. Ability of radical extirpation of the tumour decreased with each subsequent relapse. The 5-year survival rate was 60% for patients with primary combined radical resection versus 28% for patients with partial resection. In the presence of metastatic lesions the 3-year survival rate was only 22%. Conclusion: Local recurrences, the presence of distant metastases and the ability of radical extirpation are the main long-term prognostic factors.
引用
收藏
页码:649 / 654
页数:6
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