CANDIDA ENDOPHTHALMITIS - CURRENT THERAPEUTIC APPROACH

Background Candida endophthalmitis may occur either during systemic Candida infection (candidemia), particularly in immunocompromised hosts or as a single manifestation in drug abusers. Patient and methods One case of endogenous candida endophthalmitis (ECE) in a patient with systemic candiasis and four cases of drug abusers are presented. Well confined inflammatory lesions in retina and choroid were adequately treated with systemic Amphotericin B administration, whereas lesion extension beyond the internal limiting membrane towards the vitreous required surgical management, to remove epiretinal fibrovascular tissue, and intravitreal Amphotericine B injection. Conclusion In all cases, treatment resulted to regression of the lesions, however visual function recovery depends on location of chorioretinal lesions.