AN EFFICIENT SYNTHESIS OF THE BENZHYDRYLPIPERAZINE DELTA-OPIOID AGONIST (+)-BW373U86

被引：66

作者：

BISHOP, MJ

MCNUTT, RW

机构：

[1] Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 12期

关键词：

D O I：

10.1016/0960-894X(95)00213-D

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A diastereoselective version of Katritzky's method for tertiary amine formation provides an efficient route to the highly selective, non-peptidal, delta opioid agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide[(+)-BW373U86], 1.

引用

页码：1311 / 1314

页数：4

共 12 条

[1] PROBES FOR NARCOTIC RECEPTOR-MEDIATED PHENOMENA .19. SYNTHESIS OF (+)-4-[(ALPHA-R)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE (SNC-80) - A HIGHLY SELECTIVE, NONPEPTIDE DELTA-OPIOID RECEPTOR AGONIST
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