PRIMARY STRUCTURE AND LOCALIZATION OF A CONSERVED IMMUNOGENIC PLASMODIUM-FALCIPARUM GLUTAMATE RICH PROTEIN (GLURP) EXPRESSED IN BOTH THE PREERYTHROCYTIC AND ERYTHROCYTIC STAGES OF THE VERTEBRATE LIFE-CYCLE

被引：129
作者：
BORRE, MB
DZIEGIEL, M
HOGH, B
PETERSEN, E
RIENECK, K
RILEY, E
MEIS, JF
AIKAWA, M
NAKAMURA, K
HARADA, M
WIND, A
JAKOBSEN, PH
COWLAND, J
JEPSEN, S
AXELSEN, NH
VUUST, J
机构：
[1] MRC LABS, FAJARA, SENEGAMBIA
[2] CATHOLIC UNIV NIJMEGEN, INST MED MICROBIOL, NIJMEGEN, NETHERLANDS
[3] CASE WESTERN RESERVE UNIV, INST PATHOL, CLEVELAND, OH 44106 USA
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 49卷 / 01期
关键词：
PLASMODIUM-FALCIPARUM; EXOANTIGEN; GLUTAMATE-RICH PROTEIN; CONSERVATION; REPEATED SEQUENCES; T-CELL AND B-CELL SITES;
D O I：
10.1016/0166-6851(91)90135-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.
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页码：119 / 132
页数：14
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