SYNTHESIS AND EVALUATION OF A SERIES OF ARYL[E]FUSED PYRAZOLO[4,3-C]PYRIDINES WITH POTENTIAL ANXIOLYTIC ACTIVITY

被引：30

作者：

FORBES, IT ^{[1
]}

JOHNSON, CN ^{[1
]}

JONES, GE ^{[1
]}

LOUDON, J ^{[1
]}

NICHOLASS, JM ^{[1
]}

THOMPSON, M ^{[1
]}

UPTON, N ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,MRC,HARLOW,ESSEX,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 09期

关键词：

D O I：

10.1021/jm00171a046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed. © 1990, American Chemical Society. All rights reserved.

引用

页码：2640 / 2645

页数：6

共 22 条

[1] AN ANTIMALARIAL ALKALOID FROM HYDRANGEA .19. THIOPHENE ISOSTERS [J].