NKR-P1, A SIGNAL TRANSDUCTION MOLECULE ON NATURAL-KILLER-CELLS

被引：255

作者：

GIORDA, R

RUDERT, WA

VAVASSORI, C

CHAMBERS, WH

HISERODT, JC

TRUCCO, M

机构：

[1] UNIV PITTSBURGH,PITTSBURGH CANC INST,PITTSBURGH,PA 15213

[2] UNIV PITTSBURGH,DEPT PATHOL,PITTSBURGH,PA 15213

[3] UNIV PITTSBURGH,DEPT PEDIAT,PITTSBURGH,PA 15213

来源：

SCIENCE | 1990年 / 249卷 / 4974期

关键词：

D O I：

10.1126/science.2399464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural killer (NK) cells are a subpopulation of large granular lymphocytes characterized by densely staining azurophilic granules. NK cells are able to recognize and lyse various virally infected or neoplastic target cells without previous sensitization or major histocompatibility complex restriction. A 60-kD disulfide-linked dimer, highly expressed on NK cells, was found capable of mediating transmembrane signaling. The gene encoding this signal transduction molecule was cloned and its nucleotide sequence determined. The encoded protein showed significant homology with a number of lectin-related membrane proteins that share receptor characteristics. This protein may function as a receptor able to selectively trigger NK cell activity.

引用

页码：1298 / 1300

页数：3

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