ANTIBODY-RESPONSES AND SYMPTOMS AFTER DTP AND EITHER TETANUS OR DIPHTHERIA HAEMOPHILUS-INFLUENZAE TYPE-B CONJUGATE VACCINES GIVEN FOR PRIMARY IMMUNIZATION BY SEPARATE OR MIXED INJECTION

被引：24

作者：

BEGG, NT

MILLER, E

FAIRLEY, CK

CHAPEL, HM

GRIFFITHS, H

WAIGHT, PA

ASHWORTH, LAE

机构：

[1] PUBL HLTH LAB SERV,CTR COMMUNICABLE DIS SURVEILLANCE,LONDON NW9 5EQ,ENGLAND

[2] JOHN RADCLIFFE HOSP,DEPT IMMUNOL,OXFORD OX3 9DU,ENGLAND

[3] PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV PATHOL,SALISBURY SP4 0JG,WILTS,ENGLAND

来源：

VACCINE | 1995年 / 13卷 / 16期

关键词：

HAEMOPHILUS INFLUENZAE CONJUGATE VACCINE;

D O I：

10.1016/0264-410X(95)00091-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, Or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toroid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mired with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.

引用

收藏

页码：1547 / 1550

页数：4

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