LEUKOCYTE CD11/CD18 INTEGRINS - BIOLOGICAL AND CLINICAL RELEVANCE

被引:0
作者
MAZZONE, A
RICEVUTI, G
机构
关键词
CD11/CD18; INTEGRINS; LEUKOCYTES;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The integrin family consists of a series of related alpha beta heterodimers (subunits of 95,000-200,000 Mw) involved in a variety of cell-matrix and cell-cell adhesion functions. Leukocyte adhesion has biological importance in numerous processes involving host defense. The CD11/CD18 integrins are differentiated antigens which play a critical role in this mechanism. CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells. Activated granulocytes and monocytes express far more CD11b/CD18 than the other two antigens: 6 to 8x10(5) CD11b/CD18 molecules appear on maximally activated granulocytes. These integrins and in particular the beta(2) subunit are lacking in a genetic disease. On the other hand, they are fundamental in numerous physiological processes and in various hematological and cardiovascular diseases. The biochemical characterization and behavior of the CD11/CD18 complex in various clinical conditions are the subject of this review.
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页码:161 / 175
页数:15
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