PREPARATION OF ENANTIOMERICALLY PURE TERTIARY PHOSPHINE OXIDES FROM, AND ASSAY OF ENANTIOMERIC PURITY WITH, (R(P))-TERT-BUTYLPHENYLPHOSPHINOTHIOIC AND (S-P)-TERT-BUTYLPHENYLPHOSPHINOTHIOIC ACIDS

被引：56

作者：

HAYNES, RK ^{[1
]}

FREEMAN, RN ^{[1
]}

MITCHELL, CR ^{[1
]}

VONWILLER, SC ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT ORGAN CHEM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 11期

关键词：

D O I：

10.1021/jo00090a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient multigram scale method has been developed for preparation of enantiomerically-pure (R(p))- and (S-p)-tertiary phosphine oxides including allyl- and but-2-enyl-tert-butylphenylphosphine oxides wherein (R(p))- and (S-p)-tert-butyl-phenylphosphinothioic acids are converted into (R(p))- and (S-p)-tert-butylphenylphosphine oxides by ultrasound irradiation in the presence of Raney-Ni at room temperature and the secondary phosphine oxides then metalated and treated with alkyl halides.

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页码：2919 / 2921

页数：3

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