LUPUS ANTICOAGULANT ACTIVITY OF SOME ANTIPHOSPHOLIPID ANTIBODIES AGAINST PHOSPHOLIPID BOUND BETA(2)-GLYCOPROTEIN-I

被引：19
|
作者：
KEELING, DM
WILSON, AJG
MACKIE, IJ
ISENBERG, DA
MACHIN, SJ
机构：
[1] UNIV COLL & MIDDLESEX SCH MED,DEPT HAEMATOL,LONDON,ENGLAND
[2] UNIV COLL & MIDDLESEX SCH MED,DEPT RHEUMATOL,LONDON,ENGLAND
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1993年 / 46卷 / 07期
关键词：
D O I：
10.1136/jcp.46.7.665
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aims-To determine whether beta2 glycoprotein I (beta2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant activity. Methods-Six anticardiolipin antibodies were affinity purified from patients with these antibodies and lupus anticoagulant activity in their plasma. Results-The anticardiolipin antibodies bound only to anionic phospholipids in the presence of beta2GPI and bound to beta2GPI in the absence of phospholipids. Four out of six had lupus anticoagulant activity in the dilute Russell viper venom time test. Conclusions-The results show that some beta2GPI dependent aCL are lupus anticoagulants. It is unclear why only some should have lupus anticoagulant activity while others do not.
引用
收藏
页码：665 / 667
页数：3
相关论文
共 50 条
  • [41] A NEW PLAYER IN THE ANTIPHOSPHOLIPID SYNDROME - THE BETA-2 GLYCOPROTEIN-I COFACTOR
    VALESINI, G
    SHOENFELD, Y
    AUTOIMMUNITY, 1992, 14 (02) : 105 - 110
  • [42] ASSOCIATION OF ANTIMITOCHONDRIAL ANTIBODIES TYPE-5 AND ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES IN THE ANTIPHOSPHOLIPID-SYNDROME
    LAPERCHE, S
    ABUAF, N
    MEYER, O
    CARSIQUE, R
    DESCHAMPS, A
    RAJOELY, B
    JOHANET, C
    HOMBERG, JC
    JOURNAL OF RHEUMATOLOGY, 1994, 21 (09) : 1678 - 1683
  • [43] The Significance of Antibodies against Domain I of Beta-2 Glycoprotein I in Antiphospholipid Syndrome
    Kelchtermans, Hilde
    Chayoua, Walid
    de Laat, Bas
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2018, 44 (05): : 458 - 465
  • [44] STRUCTURE AND FUNCTION OF BETA(2)-GLYCOPROTEIN-I - WITH SPECIAL REFERENCE TO THE INTERACTION WITH PHOSPHOLIPID
    HAGIHARA, Y
    GOTO, Y
    KATO, H
    YOSHIMURA, T
    LUPUS, 1995, 4 : S3 - S5
  • [45] Phospholipid-dependent anti-beta(2)-glycoprotein I (beta(2)-GPI) antibodies and antiphospholipid syndrome
    Kaburaki, J
    Kuwana, M
    Yamamoto, M
    Kawai, S
    Matsuura, E
    Ikeda, Y
    INTERNAL MEDICINE, 1996, 35 (02) : 105 - 110
  • [46] Human reproductive failure is not a clinical feature associated with β2 glycoprotein-I antibodies in anticardiolipin and lupus anticoagulant seronegative patients
    Balasch, J
    Reverter, JC
    HUMAN REPRODUCTION, 2000, 15 (04) : 977 - 978
  • [47] ANTI-BETA(2) GLYCOPROTEIN-I(BETA(2)GPL) ANTIBODIES IN MRL/I MICE
    VIARD, JP
    AMOURA, Z
    CHABRE, H
    BACH, JF
    ARTHRITIS AND RHEUMATISM, 1992, 35 (09): : S356 - S356
  • [48] Antibodies to prothrombin and beta-2-glycoprotein I in lupus anticoagulant positive samples.
    Dier, KJ
    Olsen, LW
    Whittier, AM
    Fink, CA
    Lopez, LR
    BLOOD, 1999, 94 (10) : 86B - 86B
  • [49] The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta(2) glycoprotein 1 (and other proteins)
    Horkko, S
    Miller, E
    Branch, DW
    Palinski, W
    Witztum, JL
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) : 10356 - 10361
  • [50] RESISTANCE TO ACTIVATED PROTEIN-C ACTIVITY OF AN ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODY IN THE PRESENCE OF BETA(2)-GLYCOPROTEIN-I
    MATSUDA, J
    GOTOH, M
    GOHCHI, K
    KAWASUGI, K
    TSUKAMOTO, M
    SAITOH, N
    BRITISH JOURNAL OF HAEMATOLOGY, 1995, 90 (01) : 204 - 206
12345