LUPUS ANTICOAGULANT ACTIVITY OF SOME ANTIPHOSPHOLIPID ANTIBODIES AGAINST PHOSPHOLIPID BOUND BETA(2)-GLYCOPROTEIN-I

被引：19
作者：
KEELING, DM
WILSON, AJG
MACKIE, IJ
ISENBERG, DA
MACHIN, SJ
机构：
[1] UNIV COLL & MIDDLESEX SCH MED,DEPT HAEMATOL,LONDON,ENGLAND
[2] UNIV COLL & MIDDLESEX SCH MED,DEPT RHEUMATOL,LONDON,ENGLAND
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1993年 / 46卷 / 07期
关键词：
D O I：
10.1136/jcp.46.7.665
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aims-To determine whether beta2 glycoprotein I (beta2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant activity. Methods-Six anticardiolipin antibodies were affinity purified from patients with these antibodies and lupus anticoagulant activity in their plasma. Results-The anticardiolipin antibodies bound only to anionic phospholipids in the presence of beta2GPI and bound to beta2GPI in the absence of phospholipids. Four out of six had lupus anticoagulant activity in the dilute Russell viper venom time test. Conclusions-The results show that some beta2GPI dependent aCL are lupus anticoagulants. It is unclear why only some should have lupus anticoagulant activity while others do not.
引用
收藏
页码：665 / 667
页数：3
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