RELATIONSHIP BETWEEN PARACETAMOL PLASMA-LEVELS AND ITS ANALGESIC EFFECT IN THE RAT

被引：34

作者：

GRANADOSSOTO, V

FLORESMURRIETA, FJ

LOPEZMUNOZ, FJ

SALAZAR, LA

VILLARREAL, JE

CASTANEDAHERNANDEZ, G

机构：

[1] INST POLITECN NACL,DEPT FARMACOL & TOXICOL,CTR INVEST & ESTUDIOS AVANZADOS,SECC TERAPEUT EXPTL,MEXICO CITY 14000,DF,MEXICO

[2] UNIV AUTONOMA METROPOLITANA AZCAPOTZALCO,DEPT SISTEMAS BIOL,DIV SCI BIOL & SALUD,MEXICO CITY 13,DF,MEXICO

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 09期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb05511.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The relationship between plasma levels of paracetamol and its analgesic effect was studied in the rat using a model of pain-induced functional impairment (PIFI). Female Wistar rats received an intra-articular injection of 30% uric acid in the knee of the right hind limb, inducing its dysfunction. Animals then received oral paracetamol at doses of 178, 316 or 562 mg kg-1 and the recovery of functionality over time was considered as an expression of analgesia. Paracetamol plasma levels were determined by HPLC. Results showed that there is a direct relationship between paracetamol plasma levels and its analgesic effect that follows a sigmoidal model according to the Hill equation. The PIFI model appears to be a useful tool to establish pharmacokinetic/pharmacodynamic relationships for non-narcotic analgesics.

引用

页码：741 / 744

页数：4

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