EFFECT OF CHLORAMPHENICOL ON SISTER CHROMATID EXCHANGE IN BOVINE FIBROBLASTS

被引：4

作者：

ARRUGA, MV ^{[1
]}

CATALAN, J ^{[1
]}

MORENO, C ^{[1
]}

机构：

[1] VET FAC, QUANTITAT GENET SECT, E-50013 ZARAGOZA, SPAIN

来源：

RESEARCH IN VETERINARY SCIENCE | 1992年 / 52卷 / 02期

关键词：

D O I：

10.1016/0034-5288(92)90019-X

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The genotoxic potential of different chloramphenicol concentrations (5, 20, 40 and 60-mu-g ml-1) was investigated in bovine fibroblast primary lines by sister chromatid exchange assay. Chloramphenicol acted for long enough to ensure similar effects to persistent storage in the kidney. In this experiment 10-mu-g ml-1 of 5-bromodeoxyuridine was added for 60 hours for all doses of chloramphenicol and to the control. When the tissue culture cells were exposed to increasing doses, increased numbers of sister chromatid exchanges developed. Differences were significantly different to the control.

引用

页码：256 / 259

页数：4

共 39 条

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