CHIRAL ORGANOMETALLIC REAGENTS .5. A TEST ON THE CONFIGURATIONAL STABILITY OF CHIRAL ORGANOLITHIUM COMPOUNDS BASED ON KINETIC RESOLUTION - SCOPE AND LIMITATIONS

被引：64

作者：

HIRSCH, R ^{[1
]}

HOFFMANN, RW ^{[1
]}

机构：

[1] UNIV MARBURG,FACHBEREICH CHEM,HANS MEERWEIN STR,W-3550 MARBURG,GERMANY

来源：

CHEMISCHE BERICHTE-RECUEIL | 1992年 / 125卷 / 04期

关键词：

CONFIGURATIONAL STABILITY; KINETIC RESOLUTION;

D O I：

10.1002/cber.19921250432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The test on the configurational stability of chiral organolithium compounds is based on the kinetic resolution of the racemic organolithium compound on reaction with an enantiomerically pure electrophile. The limits of this test have been evaluated by model calculations. The factors that have been considered are: Optimum values for the kinetic resolution; effects of < 100% enantiomeric purity of the chiral electrophile; parallel side reactions of the organolithium compounds with the electrophile.

引用

页码：975 / 982

页数：8

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