LEAD SPECIATION BY HPLC-ICP-AES AND HPLC-ICP-MS

被引：60
作者：
ALRASHDAN, A
HEITKEMPER, D
CARUSO, JA
机构：
[1] Department of Chemistry, University of Cincinnati, Cincinnati, OH
来源：
JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1991年 / 29卷 / 03期
关键词：
D O I：
10.1093/chromsci/29.3.98
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Speciation of inorganic lead (Pb2+) and several trialkyllead species (trimethyllead chloride [TML], triethyllead chloride [TEL], and triphenyllead chloride [TPhL]) is investigated using high-performance liquid chromatography (HPLC) with detection by both inductively coupled plasma emission spectroscopy (ICP-AES), and inductively coupled plasma mass spectrometry (ICP-MS). Reversed-phase, ion-pairing, and ion-exchange HPLC modes are studied. Optimal chromatographic conditions for ICP-AES detection include a reversed-phase separation utilizing a step gradient from 10 to 70% methanol. However, the gradient has been found to destabilize the plasma when using ICP-MS detection. An isocratic separation with a 30% methanol mobile phase has been found to be the best compromise between plasma stability and chromatographic resolution. Detection limits using ICP-MS detection are 3 orders of magnitude improved over ICP-AES detection.
引用
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页码：98 / 102
页数：5
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