EFFECTS OF NUCLEUS BASALIS LESIONS ON CEREBRAL CORTICAL CONCENTRATIONS OF CORTICOTROPIN-RELEASING HORMONE (CRH)-LIKE IMMUNOREACTIVITY IN THE RAT

被引：8
|
作者：
MILLARD, WJ
ARENDASH, GW
DUNN, AJ
MEYER, EM
机构：
[1] UNIV FLORIDA, DEPT NEUROSCI, GAINESVILLE, FL 32610 USA
[2] UNIV FLORIDA, DEPT PHARMACOL, GAINESVILLE, FL 32610 USA
[3] UNIV S FLORIDA, DEPT BIOL, TAMPA, FL 33620 USA
来源：
NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期
关键词：
Acetylcholine; Cholinergic modulation; Corticotropin-releasing hormone; Nucleus basalis lesion; Parietal cortex;
D O I：
10.1016/0304-3940(90)90309-W
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study was designed to determine the effects of partial cholinergic denervation on parietal cortical corticotropin-releasing hormone-like immunoreactivity (CRH-LI) in the rat at different ages. Young adult rats received either unilateral or bilateral ibotenic acid infusions into their nucleus basalis, destroying most of the acetylcholinesterase-positive neurons in that region. Parietal cortical levels of CRH-LI were assayed 2.5, 10, 14 and 19 months after placement of nucleus basalis lesions. Parietal CRH-LI was elevated at 10, 14 and 19 months in bilaterally lesioned animals, while unilateral lesions had no effect on CRH-LI. © 1990.
引用
收藏
页码：233 / 239
页数：7
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