MITOCHONDRIAL MUTATIONS MAY INCREASE OXIDATIVE STRESS - IMPLICATIONS FOR CARCINOGENESIS AND AGING

被引：467
|
作者：
BANDY, B
DAVISON, AJ
机构：
[1] Bioenergetics Research Laboratory, School of Kinesiology, Burnaby, BC V5A 1S6, Simon Fraser Universitty
[2] Environmental Carcinogenesis Unit, B.C. Cancer Research Center, Vancouver, BC V5Z 1L3
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 06期
关键词：
Carcinogenesi; Cellular aging; Free radicals; Intracellular calcium; Lipid peroxidation; Mitochondrial mutations; Mitochondrial respiration; Oxidative stress; Superoxide;
D O I：
10.1016/0891-5849(90)90152-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sensitivity of mitochondrial DNA to damage by mutagens predisposes mitochondria to injury on exposure of cells to genotoxins or oxidative stress. Damage to the mitochondrial genome causing mutations or loss of mitochondrial gene products, or to some nuclear genes encoding mitochondrial membrane proteins, may accelerate release of reactive species of oxygen. Such aberrant mitochondria may contribute to cellular aging and promotion of cancer. © 1990.
引用
收藏
页码：523 / 539
页数：17
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