CHARACTERISTICS OF RB-86+ TRANSPORT IN HUMAN ERYTHROCYTES INFECTED WITH PLASMODIUM-FALCIPARUM

被引：16

作者：

KIRK, K ^{[1
]}

ASHWORTH, KJ ^{[1
]}

ELFORD, BC ^{[1
]}

PINCHES, RA ^{[1
]}

ELLORY, JC ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1061卷 / 02期

基金：

英国惠康基金;

关键词：

RB-86; TRANSPORT; INFECTED ERYTHROCYTE; (PLASMODIUM-FALCIPARUM); (HUMAN ERYTHROCYTE);

D O I：

10.1016/0005-2736(91)90296-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human red cells infected in vitro with Plasmodium falciparum showed a significant increase in the rate of both ouabain-sensitive and ouabain-insensitive Rb-86+ influx. The increase in ouabain-insensitive Rb-86+ influx was due, in part, to increased transport via a bumetanide-sensitive system and, in part to transport via a pathway that was absent (or at least inactive) in uninfected cells. The parasite-induced pathway was inhibited by piperine and had a dose response very similar to that of the Gardos channel of uninfected cells but was less sensitive than the Gardos channel to inhibition by quinine.

引用

页码：305 / 308

页数：4

共 50 条

[31] The malaria parasite supplies glutathione to its host cell -: Investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum
Atamna, H
Ginsburg, H
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 250 (03): : 670 - 679
[32] BINDING OF PLASMODIUM-FALCIPARUM RHOPTRY PROTEINS TO MOUSE ERYTHROCYTES AND THEIR POSSIBLE ROLE IN INVASION
SAMYELLOWE, TY
PERKINS, ME
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 39 (01) : 91 - 100
[33] Selection of peptides recognized by human antibodies against the surface of Plasmodium falciparum-infected erythrocytes
Eda, S
Sherman, IW
PARASITOLOGY, 2005, 130 : 1 - 11
[34] An in vitro microassay to assess the ability of Plasmodium falciparum-infected erythrocytes to bind to the human syncytiotrophoblast
Maubert, B
Riche, D
Deloron, P
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1998, 40 (06): : 401 - 407
[35] PLASMODIUM-FALCIPARUM - THE EFFECT OF PH AND CA2+ CONCENTRATION ON THE INVITRO CYTOADHERENCE OF INFECTED ERYTHROCYTES TO AMELANOTIC MELANOMA-CELLS
CRANDALL, I
SMITH, H
SHERMAN, IW
EXPERIMENTAL PARASITOLOGY, 1991, 73 (03) : 362 - 368
[36] Downstream effects of haemoglobinase inhibition in Plasmodium falciparum-infected erythrocytes
Naughton, Julie A.
Nasizadeh, Sima
Bell, Angus
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2010, 173 (02) : 81 - 87
[37] Cryo scanning electron microscopy of Plasmodium falciparum-infected erythrocytes
Hempel, Casper
APMIS, 2017, 125 (07) : 650 - 654
[38] OPTIMIZATION AND INHIBITION OF THE ADHERENT ABILITY OF PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES
SMITH, H
CRANDALL, I
PRUDHOMME, J
SHERMAN, IW
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 1992, 87 : 303 - 312
[39] A human schwannoma cell line supports the in vitro adhesion of Plasmodium falciparum infected erythrocytes to chondroitin-4-sulfate
K. Andrews
N. Viebig
F. Wissing
N. Klatt
N. Oster
H. Wickert
P. Knolle
M. Lanzer
Parasitology Research, 2003, 89 : 188 - 193
[40] The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes
Gavigan, CS
Dalton, JP
Bell, A
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 117 (01) : 37 - 48

← 1 2 3 4 5 →