INFLUENCE OF TETRAHYDRO-9-AMINOACRIDINE ON EXCITATORY AMINO-ACID RELEASE

被引：10

作者：

PALMER, AM ^{[1
]}

STEELE, JE ^{[1
]}

LOWE, SL ^{[1
]}

BOWEN, DM ^{[1
]}

机构：

[1] INST NEUROL,DEPT NEUROCHEM,1 WAKEFIELD ST,LONDON WC1N 1PJ,ENGLAND

来源：

CLINICAL NEUROPHARMACOLOGY | 1990年 / 13卷 / 01期

关键词：

Alzheimer's disease; Glutamic acid; Tetrahydro-9-aminoacridine; γ-Aminobutyric acid;

D O I：

10.1097/00002826-199002000-00006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease may be associated with an early and clinically relevant degeneration of some cortical excitatory amino acid-releasing neurons. Tetrahydro-9-aminoacridine (tacrine) might be an effective drug for the treatment of the disease. Various pharmacological paradigms (in rats) related to amino acid release are shown here to be modified both in vivo and in vitro by the drug. These effects are only observed with high concentrations, so it is unlikely that tacrine acts through amino acid release in humans.

引用

页码：58 / 66

页数：9

共 6 条

[1] EXCITATORY AMINO-ACID RECEPTORS AND NEURODEGENERATION
DOBLE, A
THERAPIE, 1995, 50 (04): : 319 - 337
[2] EFFECTS OF APOMORPHINE AND L-METHIONINE SULFOXIMINE ON THE RELEASE OF EXCITATORY AMINO-ACID NEUROTRANSMITTERS AND GLUTAMINE IN THE STRIATUM OF THE CONSCIOUS RAT
EXPOSITO, I
SANZ, B
PORRAS, A
MORA, F
EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (02) : 287 - 291
[3] EXCITATORY AMINO-ACID RECEPTORS, NEURAL MEMBRANE PHOSPHOLIPID-METABOLISM AND NEUROLOGICAL DISORDERS
FAROOQUI, AA
HORROCKS, LA
BRAIN RESEARCH REVIEWS, 1991, 16 (02) : 171 - 191
[4] NEURONAL ORIGINS OF K+-EVOKED AMINO-ACID RELEASE FROM CEREBELLAR CULTURES
SIMMONS, ML
DUTTON, GR
JOURNAL OF NEUROSCIENCE RESEARCH, 1992, 31 (04) : 646 - 653
[5] IκB kinase inhibition remodeled connexins, pannexin-1, and excitatory amino-acid transporters expressions to promote neuroprotection of galantamine and morphine
Magdy, Shimaa
Gamal, Maha
Samir, Nancy F.
Rashed, Laila
Emad Aboulhoda, Basma
Mohammed, Haitham S.
Sharawy, Nivin
JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 236 (11) : 7516 - 7532
[6] EXCITATORY AMINO-ACID AMPA RECEPTOR MESSENGER-RNA LOCALIZATION IN SEVERAL REGIONS OF NORMAL AND NEUROLOGICAL DISEASE AFFECTED HUMAN BRAIN - AN IN-SITU HYBRIDIZATION HISTOCHEMISTRY STUDY
GARCIALADONA, FJ
PALACIOS, JM
PROBST, A
WIESER, HG
MENGOD, G
MOLECULAR BRAIN RESEARCH, 1994, 21 (1-2): : 75 - 84

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